Patient Education: MRONJ

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What is MRONJ?

MRONJ is a rare but serious condition that affects the jawbone. It typically occurs in individuals who have been treated with certain medications known as bisphosphonates or other anti-resorptive agents. These medications are commonly used to treat conditions such as osteoporosis, bone metastases from cancer, and Paget's disease.

Risk Factors:

Several factors may increase the risk of developing MRONJ, including:

  • Long-term use of bisphosphonates or other anti-resorptive medications
  • High doses of these medications
  • Dental procedures that involve trauma to the jawbone, such as tooth extraction or dental implant placement
  • Poor oral hygiene and untreated dental infections


Symptoms of MRONJ may include:

  • Pain, swelling, or numbness in the jaw
  • Exposed bone in the mouth
  • Gum infection or inflammation
  • Poor healing of oral wounds


The treatment approach for MRONJ may vary depending on the severity of the condition and individual patient factors. Treatment options may include:

  • Antibacterial mouth rinses or oral antibiotics to manage infection
  • Pain management medications to alleviate discomfort
  • Surgical procedures to remove or debride (clean) affected bone or tissue
  • Medication adjustments or discontinuation in consultation with your healthcare provider


While not all cases of MRONJ can be prevented, there are steps you can take to reduce your risk, including:

  • Maintaining good oral hygiene practices, including regular brushing and flossing
  • Informing your dental provider about any history of bisphosphonate or anti-resorptive medication use
  • Scheduling regular dental check-ups and cleanings to monitor oral health
  • Discussing the risks and benefits of medication use with your healthcare provider


While MRONJ can be a challenging condition to manage, it's essential to remember that you're not alone. Our team is here to support you every step of the way and answer any questions you may have about your diagnosis and treatment options.

Please don't hesitate to reach out to us if you have any concerns or if you'd like to schedule a follow-up appointment to discuss your MRONJ further.